I combined the Celtic knot with the brain image to try to bring a sense of sacredness and beauty to an often taken for granted textbook image of the brain. The Celtic knot also represents an interconnected, intertwined pattern of complexity that mirrors that of our brain’s incredible connectome. Because Celtic knots were often used to decorate sacred objects and illuminate sacred manuscripts I am hoping that the viewer will make the connection that the brain too is a sacred organ and must be treated as such. In many languages, including Old English, the word for health and wholeness is the same and with this work I hope to show a whole interconnected pattern made of separate intertwined lines to represents the wholistic health of the brain and the human. The complete interweaving of my Celtic knot was compromised to include more brain anatomy such as the central and lateral sulcus but I feel this was an appropriate artistic decision. It is more important that the work represent a brain and represent a Celtic knot then accurately portray one over the other. I used a marker and watercolor pencils to render this illustration because I believe the hand drawn approach has a more organic, human touch. The imperfections are due to human hands but it still comes across as a beautiful, intricate work of art. I like the boldness and accuracy of the marker contrasted with the softness and organic textures of the watercolor.